Published in

American Society for Microbiology, Eukaryotic Cell, 9(10), p. 1257-1263, 2011

DOI: 10.1128/ec.05099-11

Links

Tools

Export citation

Search in Google Scholar

CCR4-Associated Factor 1 Coordinates the Expression of Plasmodium falciparum Egress and Invasion Proteins

Journal article published in 2011 by Bharath Balu, Steven P. Maher, Alena Pance, Chitra Chauhan, Anatoli V. Naumov, Robert M. Andrews ORCID, Peter D. Ellis, Shahid M. Khan, Jing-Wen Lin ORCID, Chris J. Janse, Julian C. Rayner, John H. Adams ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT Coordinated regulation of gene expression is a hallmark of the Plasmodium falciparum asexual blood-stage development cycle. We report that carbon catabolite repressor protein 4 (CCR4)-associated factor 1 (CAF1) is critical in regulating more than 1,000 genes during malaria parasites' intraerythrocytic stages, especially egress and invasion proteins. CAF1 knockout results in mistimed expression, aberrant accumulation and localization of proteins involved in parasite egress, and invasion of new host cells, leading to premature release of predominantly half-finished merozoites, drastically reducing the intraerythrocytic growth rate of the parasite. This study demonstrates that CAF1 of the CCR4-Not complex is a significant gene regulatory mechanism needed for Plasmodium development within the human host.