Published in

Elsevier, Progress in Molecular Biology and Translational Science, p. 359-393, 2013

DOI: 10.1016/b978-0-12-394440-5.00014-0

Links

Tools

Export citation

Search in Google Scholar

β-arrestins in the Immune System

Book chapter published in 2013 by Dianhua Jiang ORCID, Ting Xie, Jiurong Liang ORCID, Paul W. Noble
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

β-arrestins regulate G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs) through receptor desensitization while also acting as signaling scaffolds to facilitate numerous effector pathways. Recent studies have provided evidence that β-arrestins play a key role in inflammatory responses. We here summarize these advances on the roles of β-arrestins in immune regulation and inflammatory responses under physiological and pathological conditions, with an emphasis on translational implications of β-arrestins on human diseases.