Published in
Impact Journals, Oncotarget, 8(6), p. 5918-5931, 2014
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New insights into the genetics of glioblastoma multiforme by familial exome sequencing
Journal article published in 2014 by
Christina Backes,
Christian Harz,
Ulrike Fischer,
Jana Schmitt,
Kim Yj,
Nicole Ludwig,
Petersen Bs,
Britt-Sabina Petersen 
,
Sabine C. Mueller,
Mueller Sc,
Nadine M. Wolf,
Yoo-Jin Kim,
Hugo A. Katus,
Wolf Nm,
Katus Ha
and other authors.
,
Sabine C. Mueller,
Mueller Sc,
Nadine M. Wolf,
Yoo-Jin Kim,
Hugo A. Katus,
Wolf Nm,
Katus Ha
and other authors.
This paper is made freely available by the publisher.
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Abstract
Glioblastoma multiforme (GBM) is the most aggressive and malignant subtype of human brain tumors. While a family clustering of GBM has long been acknowledged, relevant hereditary factors still remained elusive. Exome sequencing of families offers the option to discover respective genetic factors.