Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Zhang, W.; Zhang, Weihua; de Geus, Eco J. C.; van Duijn, Cornelia M.; van Hoek, M.; van Haeften, T. W.; van Dam, R. M.; van Herpt, T.; van Vliet-Ostaptchouk, J.; Zillikens, M. C.; Zhao, J. H.; Ziegler, A.; Zitting, P.; van Meurs, J. B.; van Ommen, G. J.; de Faire, U.; Zhu, H.; van Gilst, W. H.; Zukowska-Szczechowska, E.; van der Schouw, Y. T.; Zhu, X.; van Dijk, K. W.; Chambers, J. C.; Li, X.; Li, Xinzhong; Kumar, Vinod; Li, Y.; Wass, Mark N.; O'reilly, P. F.; Kuehnel, Brigitte; Mateo Leach, I.; Doering, Angela; Heath, S.; Johnson, T.; Lathrop, M.; Heath, Simon; O'donnell, C. J.; Coin, L. J.; Kumar, V.; Pm, Vidal; Heard-Costa, Nancy L.; Elliott, P.; Voight, B. F.; Jc, Chambers; Hottenga, Jouke-Jan; Scott, L. J.; Steinthorsdottir,; Morris, A. P.; Dina, C.; Pf, O'Reilly; Welch, R. P.; Zeggini, E.; Kumar, M. J.; Huth, C.; McCulloch, L. J.; Jf, Peden; Ferreira, T.; Grallert, H.; Wu, G.; Willer, C. J.; Raychaudhuri, S.; McCarroll, S. A.; Langenberg, C.; Johnson, Toby; Vidal, Pedro Marques; Hofmann, O. M.; Dupuis, J.; Qi, L.; Segrè, A.; Ek, Speliotes; Navarro, P.; Boerwinkle, E.; Leach, Irene Mateo; Bonnycastle, L. L.; Bravenboer, B.; Peden, John F.; Bumpstead, S.; Burtt, N. P.; Charpentier, G.; O'Reilly, Paul F.; Cornelis, M.; Rahmioglu, Nilufer; Couper, D. J.; Crawford, G.; Bz, Alizadeh; Elliott, K. S.; Soininen, Pasi; Elliott, A. L.; Speliotes, Elizabeth K.; Erdos, M. R.; Franklin, C. S.; Ld, Atwood; Ganser, M.; Sehmi, Joban; Grarup, N.; Yuan, Xin; Green, T.; Griffin, S.; Thorleifsson, Gudmar; Groves, C. J.; Guiducci, C.; Hadjadj, S.; Ib, Borecki; Hassanali, N.; Borecki, Ingrid B.; Hyppoenen, Elina; Herder, C.; Mj, Brown; Brown, Morris J.; Aulchenko, Y. S.; Isomaa, B.; Jackson, A. U.; Johnson, P. R.; Jørgensen, T.; Kao, W. H.; Klopp, N.; Kong, A.; Charoen, Pimphen; Kraft, P.; Kuusisto, J.; Baumeister, Sebastian E.; Lauritzen, T.; Li, M.; Lieverse, A.; Cucca, Francesco; Lindgren, C. M.; Lyssenko,; Van der Harst, Pim; Das, Debashish; Marre, M.; Meitinger, T.; Midthjell, K.; Dixon, Anna L.; Palmer, C. N.; Morken,; Narisu, N.; Ej, de Geus; Nilsson, P.; Owen, K. R.; Payne, F.; Perry,; Al, Dixon; Petersen, A. K.; Eyjolfsson, Gudmundur I.; Chines, P. S.; Völzke, Henry; Döring, Angela; Platou, C. G.; Proença, C.; Doney, A. S.; Rathmann, W.; William Rayner, N.; Ehret, Georg; Robertson, N. R.; Forouhi, Nita G.; Rocheleau, G.; Roden, M.; Gudbjartsson, D. F.; Sampson, M. J.; Coin, Lachlan J.; Saxena, R.; Shrader, P.; Sigurdsson, G.; Sparsø, T.; Farrall, Martin; Strassburger, K.; Stringham, H. M.; Sun, Q.; Li, Yun; Thorand, B.; Gi, Eyjolfsson; Tichet, J.; Harris, Tamara B.; Tuomi, T.; Friedrich, Nele; Walters, G. B.; Weedon, M. N.; Wijmenga, C.; Hartikainen, Anna-Liisa; Kuehn, Jens P.; Goessling, Wolfram; Cauchi, S.; Collins, F. S.; Gloyn, A. L.; Gyllensten, U. B.; Ng, Forouhi; Hansen, T.; Hide, W. A.; Hitman, G. A.; Hirschfield, Gideon M.; Gudbjartsson, Daniel F.; Hunter, D. J.; Van Der Harst, P.; Hveem, K.; Laakso, M.; Mohlke, K. L.; Morris, A. D.; Pramstaller, P. P.; Rudan, I.; Sijbrands, E. J.; Stein, L. D.; Tuomilehto, J.; Janssen, Harry L. A.; Shields, B. M.; Walker, M.; Watanabe, R. M.; Hofman, Albert; Campbell, H.; Daly, M. J.; Hattersley, A. T.; Swift, A. J.; Hu, F. B.; Meigs, J. B.; Kangas, Antti J.; Df, Gudbjartsson; Homuth, Georg; Pankow, J. S.; Pedersen, O.; Alizadeh, Behrooz Z.; Florez, J. C.; Kema, Ido P.; Frayling, T. M.; Groop, L.; Hyppönen, Elina; Tb, Harris; Sladek, R.; Atwood, Larry D.; Kühn, Jens P.; Wilson, J. F.; Illig, T.; Al, Hartikainen; Holm, Hilma; Lango Allen, H.; Estrada, K.; Lettre, G.; Mn, Wass; Rivadeneira, F.; Vedantam, S.; Wood, A. R.; Weyant, R. J.; Lerch, Markus M.; Wheeler, E.; Soranzo, N.; Park, J. H.; Yang, J.; Chambers, John C.; Smith, A.; Gm, Hirschfield; Mägi, R.; Liang, T. Jake; Pastinen, T.; Heid, I. M.; Winkler, T. W.; Goddard, M. E.; Sin Lo, K.; Lai, Sandra; Lin, Jing-Ping; Workalemahu, T.; Johansson, A.; Feitosa,; Esko, T.; Loos, Ruth J. F.; Ketkar, S.; Mangino, M.; Ernst, F.; Glazer, N. L.; Hayward, C.; Martin, Nicholas G.; Jacobs, K. B.; Knowles, J. W.; Kutalik, Z.; Moffatt, Miriam F.; Sanna, Serena; Monda, K. L.; Polasek, O.; Preuss, M.; Rayner, N. W.; Montgomery, Grant W.; Tyrer, J. P.; Hl, Janssen; Wiklund, F.; Xu, J.; Uitterlinden, Andre G.; Munroe, Patricia B.; Pellikka, N.; Perola, M.; Randall, J. C.; Surakka, I.; Tammesoo, M. L.; Boucher, G.; Chasman, D. I.; Chen, C.; De Geus, E. J. C.; Aj, Kangas; Cooper, M. N.; Gibson, Q.; Grundberg, E.; Hao, K.; Juhani Junttila, M.; Kaplan, L. M.; Kettunen, J.; König, I. R.; Ip, Kema; Nyholt, Dale R.; Kwan, T.; Lawrence, R. W.; Penninx, Brenda W.; Levinson, D. F.; Lorentzon, M.; Kavousi, Maryam; McKnight, B.; Müller, M.; Musunuru, Kiran; Suh Ngwa, J.; Purcell, S.; Jp, Kühn; Rafelt, S.; Salem, R. M.; Prins, Bram P.; Nakamura, Yusuke; Salvi, E.; Shi, J.; Sovio, U.; Thompson,; Uitterlinden, A. G.; Turchin, M. C.; Vandenput, L.; Verlaan, D. J.; Vitart,; White, C. C.; Olafsson, Isleifur; Citterio, L.; De Grandi, A.; Dominiczak, A.; Duan, J.; Elosua, R.; Eriksson, J. G.; Savolainen, Markku J.; Pouta, Anneli; Freimer, N. B.; Mm, Lerch; Geus, E. J.; Glorioso, N.; Haiqing, S.; Havulinna, A. S.; Hicks, A. A.; Hui, J.; Schouten, Jeoffrey N. L.; Jake Liang, T.; Igl, W.; Jula, A.; Prokopenko, Inga; Kajantie, E.; McArdle, W. L.; Kilpeläinen, T. O.; Koiranen, M.; Tj, Liang; Kolcic, I.; Puls, Ralf; Koskinen, S.; Kovacs, P.; Laitinen, J.; Siminovitch, Katherine A.; Liu, J.; Lokki, M. L.; Ruokonen, Aimo; Marusic, A.; Maschio, A.; Mulas, A.; Smit, Johannes H.; Jp, Lin; Paré, G.; Parker, A. N.; Petersmann, A.; Witteman, Jacqueline C. M.; Pichler, I.; Spector, Timothy D.; Ridderstråle, M.; Schlessinger, David; Rotter, J. I.; Sambrook, J. G.; Rj, Loos; Jj, Hottenga; Sanders, A. R.; Palmer, L. J.; Schmidt, C. O.; Sinisalo, J.; Widen, E.; Teslovich, Tanya M.; Wild, S. H.; Zagato, L.; Seedorf, Udo; Launer, L. J.; Zgaga, L.; Ng, Martin; Nelis, M.; Peters, M. J.; Sen-Chowdhry, Srijita; Ripatti, S.; Cusi, D.; Oostra, B.; Mf, Moffatt; Den Heijer, M.; Eiriksdottir, G.; Gejman, P.; Hamsten, A.; Van Der Klauw, M. M.; Huikuri, H.; Iribarren, C.; Gw, Montgomery; Vasan, Ramachandran S.; Kähönen, M.; Lathrop, G. Mark; Palmer, C. D.; Kaprio, J.; Kühnel, Brigitte; Kathiresan, S.; Kiemeney, L.; Kocher, T.; Pb, Munroe; Deng, Guohong; Lehtimäki, T.; Melander, O.; Mosley, T. H.; Tan, Wenting; Musk, A. W.; Nieminen,; Ohlsson, C.; Raitakari, O.; Ridker, P. M.; Wichmann, H.-Erich; Rioux,; Ardlie, K. G.; Rissanen, A.; Rivolta, C.; Tukiainen, Taru; Schunkert, H.; Shuldiner, A. R.; Siscovick, D. S.; Stumvoll, M.; Tönjes, A.; Cj, O'Donnell; Viikari, J.; Heath, A. C.; Province,; Kayser, M.; Groop, L. C.; Chanock, S. J.; Deloukas, P.; Grönberg, H.; Hall, P.; Yerges-Armstrong, Laura M.; Hengstenberg, C.; Hoffman, W.; Wallace, Chris; Salomaa,; Schreiber, S.; Bw, Penninx; Gieger, Christian; Waterworth, D. M.; Wright, A. F.; Cupples, L. A.; Erdmann, J.; Gudnason,; O'Donnell, Christopher J.; Wallaschofski, Henri; Hayes, R. B.; Ouwehand, W. H.; Quertermous, T.; Van der Klauw, Melanie M.; Samani, N. J.; Lagou, Vasiliki; McArdle, W.; Boomsma, Dorret I.; Haritunians, T.; Ehret, Georg B.; Kaplan, R. C.; Witteman, J. C. M.; Metspalu, A.; Bp, Prins; North, K. E.; O'connell, J.; Willemsen, Gonneke; Strachan, D. P.; Peltonen, L.; Visscher, P. M.; Cookson, William O.; Chatterjee, N.; Würtz, Peter; Ingelsson, E.; Hirschhorn, J. N.; Edmondson, A. C.; Oostra,; Stylianou, I. M.; Koseki, M.; Pirruccello, J. P.; Xu, Chun; Johansen, C. T.; Fouchier, S. W.; Liang, Liming; Isaacs, A.; Waterworth, Dawn M.; Peloso, G. M.; Ricketts, S. L.; Orho-Melander, M.; Guo, X.; Cho, Y. S.; Go, M. J.; Kim, Y. J.; Lee, J. Y.; McCarthy, Mark I.; Caulfield, Mark J.; Park, T.; Kim, K.; Mj, Savolainen; Sim, X.; Ong, R. T.; Se, Baumeister; Croteau-Chonka, D. C.; Lange, L. A.; Smith,; Song, K.; Lamina, C.; Zee, R. Y.; Tanaka, T.; Silander, K.; Scuteri, A.; Salomaa, J.; Luan, Jian'an; Pietiläinen, Kirsi H.; Sabatti, C.; Rose, L. M.; Amin, N.; Roberts, R.; Caulfield, Mark; Rieder, M.; Launer, L.; Jn, Schouten; Psaty, B. M.; Pedersen, N. L.; Pattaro, C.; Pare, G.; Balkau, B.; Nickerson, D. A.; Benediktsson, R.; Bennett, A. J.; Sternberg, Michael J. E.; Wuertz, Peter; McPherson, R.; Blagieva, R.; Masson, D.; Bengtsson Boström, K.; Froguel, Philippe; Stolk, Ronald P.; Marroni, F.; Magnusson, P. K.; Lucas, G.; Luben, R.; Lakatta, E. G.; Dominiczak, A. F.; Matsuda, Koichi; Laaksonen, R.; Thomas, Howard C.; Kyvik, K. O.; Kronenberg, F.; Khaw, K. T.; Ka, Siminovitch; Janssens, A. C.; Hovingh, G. K.; Hastie, N. D.; Hall, A. S.; Gonzalez, E.; Jh, Smit; Gieger, N. B.; Meisinger, Christa; Ferrucci, L.; Ejebe, K. G.; Demissie, S.; Chen, Y. D.; Lj, Coin; Seielstad, M.; Td, Spector; Mooser, Vincent; Wong, T. Y.; Tai, E. S.; Feranil,; Kuzawa, C. W.; Taylor, H. A.; Gabriel, S. B.; Wilson, J. G.; Wareham, Nicholas J.; Krauss, R. M.; Ordovas, J. M.; Abecasis, Goncalo R.; Tall, A. R.; Bergman,; Hegele, R. A.; Schumann, Gunter; Sehmi, Joban S.; Kastelein, J. J.; Ahmadi, Kourosh R.; Tm, Teslovich; Reilly,; Sandhu, M.; Rader, D. J.; Snieder, Harold; Hernaez, R.; Kim, L. J.; Nalls,; Clark, J. M.; Boehm, B. O.; Whitfield, John B.; Mitchell, B. D.; Butler, J. L.; Ag, Uitterlinden; Tomas, M.; Hoffmann, U.; Barroso, I.; Hwang, S. J.; Massaro, J. M.; Sahani, D.; Altshuler, D.; Wolffenbuttel, Bruce H. R.; Schwartz, S. M.; Boehnke, M.; Carr, J. J.; Jarvelin, Marjo-Riitta; Mm, Van der Klauw; Berndt, S. I.; Fox, Caroline S.; Johnson, A. D.; Thorsteinsdottir, Unnur; Tobin,; Verwoert, G. C.; Erich Wichmann, H.; Pihur,; Bragg-Gresham, J. L.; Rs, Vasan; Uda, Manuela; Teumer, A.; Garcia, M. E.; Sober, S.; Parsa, A.; Dehghan, A.; Zhang, F.; Milaneschi, Y.; Waeber, Gérard; Absher, D.; Fava, C.; Albrecht, E.; Fox, E. R.; Kumari, M.; Sjogren, M.; Vinay, D. G.; Tabara, Y.; Palmer, N. D.; Rice, K. M.; Shaw-Hawkins, S.; Schadt, Eric E.; Whincup, P. H.; Liu, Y.; Shi, G.; He, Wichmann; Watkins, Hugh; Altmaier, E. L.; Tayo, B.; Aspelund, T.; Nguyen, K. D.; Bhangale, T.; Lehtimaki, T.; Järvelin, Marjo-Riitta; Matullo, G.; Wu, Y.; Gaunt, T. R.; Onland-Moret, N. C.; Org, E.; Hardy, R.; Dahgam, S.; Palmen, J.; Braund, P. S.; Kuznetsova, T.; Uiterwaal, C. S.; Palmas, W.; Kooner, Jaspal S.; Ludwig, B.; Tomaszewski, M.; Almgren, P.; Tzoulaki, I.; Balmforth, A. J.; Chang, Y. P.; Steinle, N. I.; Lm, Yerges Armstrong; Grobbee, D. E.; Kardia, S. L.; Morrison, A. C.; Hernandez, D.; Najjar, S.; Stefansson, Kari; Hadley, D.; Consortium, Alcohol Genome-Wide Association (AlcGen); Connell, J. M.; Hingorani, A. D.; Day, I. N.; Lawlor, D. A.; Clarke, R.; Vollenweider, Peter; Collins, R.; Hopewell, J. C.; Ongen, H.; Study, Diabetes Genetics Replication and Meta-Analyses (Diagram+); Dreisbach, A. W.; Young, J. H.; Kahonen, M.; Lee, N. R.; Alavere, H.; Chen, M. H.; Olden, M.; Bolton, J. A.; Aben, K. K.; Consortium, Genetic Investigation of Anthropometric Traits (GIANT); Kottgen, A.; Chaturvedi, N. R.; Scott, James; Beckmann, J. S.; Beilby, J. P.; Islam, M.; Bergmann, S.; Jafar, T. H.; Kulkarni,; Bornstein,; Grassler, J.; Howard, P.; Consortium, Global Lipids Genetics; Taylor, A.; Guarrera, S.; Ricceri, F.; Emilsson,; Ala-Korpela, Mika; Plump, A.; Consortium, Genetics of Liver Disease (GOLD); Weder,; Hunt, S. C.; Sun, Y.; Vartiainen, E.; Brand, S. M.; Staessen, J. A.; Wang, T. J.; Van Duijn, C. M.; Gwas), International Consortium for Blood Pressure (ICBP; Arnold, A. M.; Nl, Heard Costa; Burton, P. R.; Dong, Y.; Wang, X.; Lohman, K. K.; Rudock, M. E.; (Magic), Meta-Analyses of Glucose and Insulin-Related Traits Consortium; Assimes, T. L.; Heckbert,; Smith, N. L.; Wiggins, K. L.; Doumatey, A.; Shriner, D.; Veldre, G.; Gr, Abecasis; Viigimaa, M.; Kinra, S.; Prabhakaran, D.; Tripathy,; Langefeld, C. D.; Rosengren, A.; Kr, Ahmadi; Thelle, D. S.; Corsi, A. M.; Singleton, A.; Barbalic, M.; Forrester, T.; Bis, J. C.; Hilton, G.; McKenzie, C. A.; Salako, T.; Di, Boomsma; Iwai, N.; Kita, Y.; Ogihara, T.; Ohkubo, T.; Okamura, T.; Ueshima, H.; Umemura, S.; Eyheramendy, S.; Kim, H. L.; Elliott, Paul; Hedblad, B.; Smith, G. D.; Wong, A.; Stančakova, A.; Wo, Cookson; Raffel, L. J.; Yao, J.; O'donnell, C.; Voelzke, Henry; Ikram,; Longstreth, W. T.; Seshadri, S.; Shrine, N. R.; Cm, van Duijn; Wain, L.; Cooper, J. A.; Humphries, S. E.; Danesh, J.; Bandinelli, S.; Rasheed, A.; Ballantyne, C. M.; Goel, A.; Ballantyne, T. L.; Janipalli, C. S.; Mani, K. R.; Boekholdt, S. Matthijs; Adair, L. S.; Yajnik, C. S.; Mattace-Raso, F. U.; Demirkan, A.; Orru, M.; Lyytikainen, L. P.; Wurz, P.; Dorr, M.; Mi, McCarthy; Kroemer, H. K.; Volker, U.; Galan, P.; Hercberg, S.; Zelenika, D.; Zhai, G.; Meschia, J. F.; Bochud, M.; Sharma, P.; Terzic, J.; Denniff, M.; Wagenknecht, L. E.; Fowkes, F. G.; Arora, P.; Charchar, F. J.; Replication, Diabet Genetics; Rotimi, C.; Bots, M. L.; Brand, E.; Kh, Pietiläinen; Alexander, M.; Talmud, P. J.; Nyberg, F.; Kuh, D.; Laan, M.; Casas, J. P.; Vineis, P.; Marmot, M. G.; Ganesh, S. K.; Cooper, R. S.; Rao, D. C.; Morris, R. W.; Adeyemo, A.; Kivimaki, M.; Miki, T.; Saleheen, D.; Chandak, G. R.; Coresh, J.; Schwarz, P. E.; Navis, G.; Arking, D. E.; Han, B. G.; Meneton, P.; Mj, Sternberg; Rettig, R.; Larson, M. G.; Chakravarti, A.; Newton-Cheh, C.; Levy, D.; Icbp, Int Consortium Blood Pressure; Bouatia-Naji, N.; Rp, Stolk; Rybin, D.; Henneman, P.; Egan, J. M.; Lajunen, T.; Kanoni, S.; Cavalcanti-Proença, C.; Hc, Thomas; Timpson, N. J.; Zabena, C.; Insulin-Related, Meta-Anal Glucose; Artigas,; Elliott, A.; Roccasecca, R. M.; Pattou, F.; Sethupathy, P.; Bumpstead, S. J.; Bonnefond, A.; Borch-Johnsen, K.; Böttcher, Y.; Brunner, E.; Crisponi, L.; Delplanque, J.; Fedson, A. C.; Fischer-Rosinsky, A.; Frants, R.; Franzosi, M. G.; Goodarzi, M. O.; Graessler, J.; Nj, Wareham; Heath, S. C.; Grundy, S.; Gwilliam, R.; Völzke, H.; Hallmans, G.; Hammond, N.; Han, X.; Hillman, D. R.; Bakker, S. J.; Dm, Waterworth; Hung, J.; Kaakinen, M.; Kesaniemi, Y. A.; Knight, B.; Le Bacquer, O.; Lecoeur, C.; Mahley, R.; Manning, A. K.; Martínez-Larrad, M. T.; McAteer, J. B.; Marmot, M.; Melzer, D.; Meyre, D.; Mukherjee, S.; Jb, Whitfield; Naitza, S.; Neville, M. J.; Orrù, M.; Pakyz, R.; Paolisso, G.; Jc, Witteman; Pearson, D.; Pfeiffer, A. F.; Posthuma, D.; Potter, S. C.; Rolandsson, O.; Sandbaek, A.; Sayer, A. A.; Bh, Wolffenbuttel; Consortium, Genetics Liver Dis Gold; Scheet, P.; Sharp, S. J.; Sigurethsson, G.; Silveira, A.; Simpson, L.; Cs, Fox; Syddall, H.; Syvänen, A. C.; Other, And; An, P.; Varma, D.; Visvikis-Siest, S.; Vogelzangs, N.; Wagner, P. J.; Ariyurek, Y.; Walley, A.; Barter, P.; Ward, K. L.; Ben-Shlomo, Y.; Yarnell, J. W.; Zethelius, B.; Nathan, D. M.; Williams, G. H.; Spranger, J.; Karpe, F.; Cooper, C.; Dedoussis, G.; Serrano-Ríos, M.; Lind, L.; Franks, P. W.; Ebrahim, S.; Buchanan, T. A.; Valle, T. T.; Ee, Schadt; Cao, A.; Mr, Järvelin; Js, Kooner; AlcGen, Alcohol Genome-Wide Assoc; Anthropometric, Genetic Invest; Barroso,

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Peter P. Pramstaller
Zhang et al., 2011

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Nature Research, Nature Genetics, 11(43), p. 1131-1138, 2011

DOI: 10.1038/ng.970

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@article{Zhang2011,
  author = {Zhang, W. and Zhang, Weihua and de Geus, Eco J. C. and van Duijn, Cornelia M. and van Hoek, M. and van Haeften, T. W. and van Dam, R. M. and van Herpt, T. and van Vliet-Ostaptchouk, J. and Zillikens, M. C. and Zhao, J. H. and Ziegler, A. and Zitting, P. and van Meurs, J. B. and van Ommen, G. J. and de Faire, U. and Zhu, H. and van Gilst, W. H. and Zukowska-Szczechowska, E. and van der Schouw, Y. T. and Zhu, X. and van Dijk, K. W. and Chambers, J. C. and Li, X. and Li, Xinzhong and Kumar, Vinod and Li, Y. and Wass, Mark N. and O'reilly, P. F. and Kuehnel, Brigitte and Mateo Leach, I. and Doering, Angela and Heath, S. and Johnson, T. and Lathrop, M. and Heath, Simon and O'donnell, C. J. and Coin, L. J. and Kumar, V. and Pm, Vidal and Heard-Costa, Nancy L. and Elliott, P. and Voight, B. F. and Jc, Chambers and Hottenga, Jouke-Jan and Scott, L. J. and Steinthorsdottir,  and Morris, A. P. and Dina, C. and Pf, O'Reilly and Welch, R. P. and Zeggini, E. and Kumar, M. J. and Huth, C. and McCulloch, L. J. and Jf, Peden and Ferreira, T. and Grallert, H. and Wu, G. and Willer, C. J. and Raychaudhuri, S. and McCarroll, S. A. and Langenberg, C. and Johnson, Toby and Vidal, Pedro Marques and Hofmann, O. M. and Dupuis, J. and Qi, L. and Segrè, A. and Ek, Speliotes and Navarro, P. and Boerwinkle, E. and Leach, Irene Mateo and Bonnycastle, L. L. and Bravenboer, B. and Peden, John F. and Bumpstead, S. and Burtt, N. P. and Charpentier, G. and O'Reilly, Paul F. and Cornelis, M. and Rahmioglu, Nilufer and Couper, D. J. and Crawford, G. and Bz, Alizadeh and Elliott, K. S. and Soininen, Pasi and Elliott, A. L. and Speliotes, Elizabeth K. and Erdos, M. R. and Franklin, C. S. and Ld, Atwood and Ganser, M. and Sehmi, Joban and Grarup, N. and Yuan, Xin and Green, T. and Griffin, S. and Thorleifsson, Gudmar and Groves, C. J. and Guiducci, C. and Hadjadj, S. and Ib, Borecki and Hassanali, N. and Borecki, Ingrid B. and Hyppoenen, Elina and Herder, C. and Mj, Brown and Brown, Morris J. and Aulchenko, Y. S. and Isomaa, B. and Jackson, A. U. and Johnson, P. R. and Jørgensen, T. and Kao, W. H. and Klopp, N. and Kong, A. and Charoen, Pimphen and Kraft, P. and Kuusisto, J. and Baumeister, Sebastian E. and Lauritzen, T. and Li, M. and Lieverse, A. and Cucca, Francesco and Lindgren, C. M. and Lyssenko,  and Van der Harst, Pim and Das, Debashish and Marre, M. and Meitinger, T. and Midthjell, K. and Dixon, Anna L. and Palmer, C. N. and Morken,  and Narisu, N. and Ej, de Geus and Nilsson, P. and Owen, K. R. and Payne, F. and Perry,  and Al, Dixon and Petersen, A. K. and Eyjolfsson, Gudmundur I. and Chines, P. S. and Völzke, Henry and Döring, Angela and Platou, C. G. and Proença, C. and Doney, A. S. and Rathmann, W. and William Rayner, N. and Ehret, Georg and Robertson, N. R. and Forouhi, Nita G. and Rocheleau, G. and Roden, M. and Gudbjartsson, D. F. and Sampson, M. J. and Coin, Lachlan J. and Saxena, R. and Shrader, P. and Sigurdsson, G. and Sparsø, T. and Farrall, Martin and Strassburger, K. and Stringham, H. M. and Sun, Q. and Li, Yun and Thorand, B. and Gi, Eyjolfsson and Tichet, J. and Harris, Tamara B. and Tuomi, T. and Friedrich, Nele and Walters, G. B. and Weedon, M. N. and Wijmenga, C. and Hartikainen, Anna-Liisa and Kuehn, Jens P. and Goessling, Wolfram and Cauchi, S. and Collins, F. S. and Gloyn, A. L. and Gyllensten, U. B. and Ng, Forouhi and Hansen, T. and Hide, W. A. and Hitman, G. A. and Hirschfield, Gideon M. and Gudbjartsson, Daniel F. and Hunter, D. J. and Van Der Harst, P. and Hveem, K. and Laakso, M. and Mohlke, K. L. and Morris, A. D. and Pramstaller, P. P. and Rudan, I. and Sijbrands, E. J. and Stein, L. D. and Tuomilehto, J. and Janssen, Harry L. A. and Shields, B. M. and Walker, M. and Watanabe, R. M. and Hofman, Albert and Campbell, H. and Daly, M. J. and Hattersley, A. T. and Swift, A. J. and Hu, F. B. and Meigs, J. B. and Kangas, Antti J. and Df, Gudbjartsson and Homuth, Georg and Pankow, J. S. and Pedersen, O. and Alizadeh, Behrooz Z. and Florez, J. C. and Kema, Ido P. and Frayling, T. M. and Groop, L. and Hyppönen, Elina and Tb, Harris and Sladek, R. and Atwood, Larry D. and Kühn, Jens P. and Wilson, J. F. and Illig, T. and Al, Hartikainen and Holm, Hilma and Lango Allen, H. and Estrada, K. and Lettre, G. and Mn, Wass and Rivadeneira, F. and Vedantam, S. and Wood, A. R. and Weyant, R. J. and Lerch, Markus M. and Wheeler, E. and Soranzo, N. and Park, J. H. and Yang, J. and Chambers, John C. and Smith, A. and Gm, Hirschfield and Mägi, R. and Liang, T. Jake and Pastinen, T. and Heid, I. M. and Winkler, T. W. and Goddard, M. E. and Sin Lo, K. and Lai, Sandra and Lin, Jing-Ping and Workalemahu, T. and Johansson, A. and Feitosa,  and Esko, T. and Loos, Ruth J. F. and Ketkar, S. and Mangino, M. and Ernst, F. and Glazer, N. L. and Hayward, C. and Martin, Nicholas G. and Jacobs, K. B. and Knowles, J. W. and Kutalik, Z. and Moffatt, Miriam F. and Sanna, Serena and Monda, K. L. and Polasek, O. and Preuss, M. and Rayner, N. W. and Montgomery, Grant W. and Tyrer, J. P. and Hl, Janssen and Wiklund, F. and Xu, J. and Uitterlinden, Andre G. and Munroe, Patricia B. and Pellikka, N. and Perola, M. and Randall, J. C. and Surakka, I. and Tammesoo, M. L. and Boucher, G. and Chasman, D. I. and Chen, C. and De Geus, E. J. C. and Aj, Kangas and Cooper, M. N. and Gibson, Q. and Grundberg, E. and Hao, K. and Juhani Junttila, M. and Kaplan, L. M. and Kettunen, J. and König, I. R. and Ip, Kema and Nyholt, Dale R. and Kwan, T. and Lawrence, R. W. and Penninx, Brenda W. and Levinson, D. F. and Lorentzon, M. and Kavousi, Maryam and McKnight, B. and Müller, M. and Musunuru, Kiran and Suh Ngwa, J. and Purcell, S. and Jp, Kühn and Rafelt, S. and Salem, R. M. and Prins, Bram P. and Nakamura, Yusuke and Salvi, E. and Shi, J. and Sovio, U. and Thompson,  and Uitterlinden, A. G. and Turchin, M. C. and Vandenput, L. and Verlaan, D. J. and Vitart,  and White, C. C. and Olafsson, Isleifur and Citterio, L. and De Grandi, A. and Dominiczak, A. and Duan, J. and Elosua, R. and Eriksson, J. G. and Savolainen, Markku J. and Pouta, Anneli and Freimer, N. B. and Mm, Lerch and Geus, E. J. and Glorioso, N. and Haiqing, S. and Havulinna, A. S. and Hicks, A. A. and Hui, J. and Schouten, Jeoffrey N. L. and Jake Liang, T. and Igl, W. and Jula, A. and Prokopenko, Inga and Kajantie, E. and McArdle, W. L. and Kilpeläinen, T. O. and Koiranen, M. and Tj, Liang and Kolcic, I. and Puls, Ralf and Koskinen, S. and Kovacs, P. and Laitinen, J. and Siminovitch, Katherine A. and Liu, J. and Lokki, M. L. and Ruokonen, Aimo and Marusic, A. and Maschio, A. and Mulas, A. and Smit, Johannes H. and Jp, Lin and Paré, G. and Parker, A. N. and Petersmann, A. and Witteman, Jacqueline C. M. and Pichler, I. and Spector, Timothy D. and Ridderstråle, M. and Schlessinger, David and Rotter, J. I. and Sambrook, J. G. and Rj, Loos and Jj, Hottenga and Sanders, A. R. and Palmer, L. J. and Schmidt, C. O. and Sinisalo, J. and Widen, E. and Teslovich, Tanya M. and Wild, S. H. and Zagato, L. and Seedorf, Udo and Launer, L. J. and Zgaga, L. and Ng, Martin and Nelis, M. and Peters, M. J. and Sen-Chowdhry, Srijita and Ripatti, S. and Cusi, D. and Oostra, B. and Mf, Moffatt and Den Heijer, M. and Eiriksdottir, G. and Gejman, P. and Hamsten, A. and Van Der Klauw, M. M. and Huikuri, H. and Iribarren, C. and Gw, Montgomery and Vasan, Ramachandran S. and Kähönen, M. and Lathrop, G. Mark and Palmer, C. D. and Kaprio, J. and Kühnel, Brigitte and Kathiresan, S. and Kiemeney, L. and Kocher, T. and Pb, Munroe and Deng, Guohong and Lehtimäki, T. and Melander, O. and Mosley, T. H. and Tan, Wenting and Musk, A. W. and Nieminen,  and Ohlsson, C. and Raitakari, O. and Ridker, P. M. and Wichmann, H.-Erich and Rioux,  and Ardlie, K. G. and Rissanen, A. and Rivolta, C. and Tukiainen, Taru and Schunkert, H. and Shuldiner, A. R. and Siscovick, D. S. and Stumvoll, M. and Tönjes, A. and Cj, O'Donnell and Viikari, J. and Heath, A. C. and Province,  and Kayser, M. and Groop, L. C. and Chanock, S. J. and Deloukas, P. and Grönberg, H. and Hall, P. and Yerges-Armstrong, Laura M. and Hengstenberg, C. and Hoffman, W. and Wallace, Chris and Salomaa,  and Schreiber, S. and Bw, Penninx and Gieger, Christian and Waterworth, D. M. and Wright, A. F. and Cupples, L. A. and Erdmann, J. and Gudnason,  and O'Donnell, Christopher J. and Wallaschofski, Henri and Hayes, R. B. and Ouwehand, W. H. and Quertermous, T. and Van der Klauw, Melanie M. and Samani, N. J. and Lagou, Vasiliki and McArdle, W. and Boomsma, Dorret I. and Haritunians, T. and Ehret, Georg B. and Kaplan, R. C. and Witteman, J. C. M. and Metspalu, A. and Bp, Prins and North, K. E. and O'connell, J. and Willemsen, Gonneke and Strachan, D. P. and Peltonen, L. and Visscher, P. M. and Cookson, William O. and Chatterjee, N. and Würtz, Peter and Ingelsson, E. and Hirschhorn, J. N. and Edmondson, A. C. and Oostra,  and Stylianou, I. M. and Koseki, M. and Pirruccello, J. P. and Xu, Chun and Johansen, C. T. and Fouchier, S. W. and Liang, Liming and Isaacs, A. and Waterworth, Dawn M. and Peloso, G. M. and Ricketts, S. L. and Orho-Melander, M. and Guo, X. and Cho, Y. S. and Go, M. J. and Kim, Y. J. and Lee, J. Y. and McCarthy, Mark I. and Caulfield, Mark J. and Park, T. and Kim, K. and Mj, Savolainen and Sim, X. and Ong, R. T. and Se, Baumeister and Croteau-Chonka, D. C. and Lange, L. A. and Smith,  and Song, K. and Lamina, C. and Zee, R. Y. and Tanaka, T. and Silander, K. and Scuteri, A. and Salomaa, J. and Luan, Jian'an and Pietiläinen, Kirsi H. and Sabatti, C. and Rose, L. M. and Amin, N. and Roberts, R. and Caulfield, Mark and Rieder, M. and Launer, L. and Jn, Schouten and Psaty, B. M. and Pedersen, N. L. and Pattaro, C. and Pare, G. and Balkau, B. and Nickerson, D. A. and Benediktsson, R. and Bennett, A. J. and Sternberg, Michael J. E. and Wuertz, Peter and McPherson, R. and Blagieva, R. and Masson, D. and Bengtsson Boström, K. and Froguel, Philippe and Stolk, Ronald P. and Marroni, F. and Magnusson, P. K. and Lucas, G. and Luben, R. and Lakatta, E. G. and Dominiczak, A. F. and Matsuda, Koichi and Laaksonen, R. and Thomas, Howard C. and Kyvik, K. O. and Kronenberg, F. and Khaw, K. T. and Ka, Siminovitch and Janssens, A. C. and Hovingh, G. K. and Hastie, N. D. and Hall, A. S. and Gonzalez, E. and Jh, Smit and Gieger, N. B. and Meisinger, Christa and Ferrucci, L. and Ejebe, K. G. and Demissie, S. and Chen, Y. D. and Lj, Coin and Seielstad, M. and Td, Spector and Mooser, Vincent and Wong, T. Y. and Tai, E. S. and Feranil,  and Kuzawa, C. W. and Taylor, H. A. and Gabriel, S. B. and Wilson, J. G. and Wareham, Nicholas J. and Krauss, R. M. and Ordovas, J. M. and Abecasis, Goncalo R. and Tall, A. R. and Bergman,  and Hegele, R. A. and Schumann, Gunter and Sehmi, Joban S. and Kastelein, J. J. and Ahmadi, Kourosh R. and Tm, Teslovich and Reilly,  and Sandhu, M. and Rader, D. J. and Snieder, Harold and Hernaez, R. and Kim, L. J. and Nalls,  and Clark, J. M. and Boehm, B. O. and Whitfield, John B. and Mitchell, B. D. and Butler, J. L. and Ag, Uitterlinden and Tomas, M. and Hoffmann, U. and Barroso, I. and Hwang, S. J. and Massaro, J. M. and Sahani, D. and Altshuler, D. and Wolffenbuttel, Bruce H. R. and Schwartz, S. M. and Boehnke, M. and Carr, J. J. and Jarvelin, Marjo-Riitta and Mm, Van der Klauw and Berndt, S. I. and Fox, Caroline S. and Johnson, A. D. and Thorsteinsdottir, Unnur and Tobin,  and Verwoert, G. C. and Erich Wichmann, H. and Pihur,  and Bragg-Gresham, J. L. and Rs, Vasan and Uda, Manuela and Teumer, A. and Garcia, M. E. and Sober, S. and Parsa, A. and Dehghan, A. and Zhang, F. and Milaneschi, Y. and Waeber, Gérard and Absher, D. and Fava, C. and Albrecht, E. and Fox, E. R. and Kumari, M. and Sjogren, M. and Vinay, D. G. and Tabara, Y. and Palmer, N. D. and Rice, K. M. and Shaw-Hawkins, S. and Schadt, Eric E. and Whincup, P. H. and Liu, Y. and Shi, G. and He, Wichmann and Watkins, Hugh and Altmaier, E. L. and Tayo, B. and Aspelund, T. and Nguyen, K. D. and Bhangale, T. and Lehtimaki, T. and Järvelin, Marjo-Riitta and Matullo, G. and Wu, Y. and Gaunt, T. R. and Onland-Moret, N. C. and Org, E. and Hardy, R. and Dahgam, S. and Palmen, J. and Braund, P. S. and Kuznetsova, T. and Uiterwaal, C. S. and Palmas, W. and Kooner, Jaspal S. and Ludwig, B. and Tomaszewski, M. and Almgren, P. and Tzoulaki, I. and Balmforth, A. J. and Chang, Y. P. and Steinle, N. I. and Lm, Yerges Armstrong and Grobbee, D. E. and Kardia, S. L. and Morrison, A. C. and Hernandez, D. and Najjar, S. and Stefansson, Kari and Hadley, D. and Consortium, Alcohol Genome-Wide Association (AlcGen) and Connell, J. M. and Hingorani, A. D. and Day, I. N. and Lawlor, D. A. and Clarke, R. and Vollenweider, Peter and Collins, R. and Hopewell, J. C. and Ongen, H. and Study, Diabetes Genetics Replication and Meta-Analyses (Diagram+) and Dreisbach, A. W. and Young, J. H. and Kahonen, M. and Lee, N. R. and Alavere, H. and Chen, M. H. and Olden, M. and Bolton, J. A. and Aben, K. K. and Consortium, Genetic Investigation of Anthropometric Traits (GIANT) and Kottgen, A. and Chaturvedi, N. R. and Scott, James and Beckmann, J. S. and Beilby, J. P. and Islam, M. and Bergmann, S. and Jafar, T. H. and Kulkarni,  and Bornstein,  and Grassler, J. and Howard, P. and Consortium, Global Lipids Genetics and Taylor, A. and Guarrera, S. and Ricceri, F. and Emilsson,  and Ala-Korpela, Mika and Plump, A. and Consortium, Genetics of Liver Disease (GOLD) and Weder,  and Hunt, S. C. and Sun, Y. and Vartiainen, E. and Brand, S. M. and Staessen, J. A. and Wang, T. J. and Van Duijn, C. M. and Gwas), International Consortium for Blood Pressure (ICBP and Arnold, A. M. and Nl, Heard Costa and Burton, P. R. and Dong, Y. and Wang, X. and Lohman, K. K. and Rudock, M. E. and (Magic), Meta-Analyses of Glucose and Insulin-Related Traits Consortium and Assimes, T. L. and Heckbert,  and Smith, N. L. and Wiggins, K. L. and Doumatey, A. and Shriner, D. and Veldre, G. and Gr, Abecasis and Viigimaa, M. and Kinra, S. and Prabhakaran, D. and Tripathy,  and Langefeld, C. D. and Rosengren, A. and Kr, Ahmadi and Thelle, D. S. and Corsi, A. M. and Singleton, A. and Barbalic, M. and Forrester, T. and Bis, J. C. and Hilton, G. and McKenzie, C. A. and Salako, T. and Di, Boomsma and Iwai, N. and Kita, Y. and Ogihara, T. and Ohkubo, T. and Okamura, T. and Ueshima, H. and Umemura, S. and Eyheramendy, S. and Kim, H. L. and Elliott, Paul and Hedblad, B. and Smith, G. D. and Wong, A. and Stančakova, A. and Wo, Cookson and Raffel, L. J. and Yao, J. and O'donnell, C. and Voelzke, Henry and Ikram,  and Longstreth, W. T. and Seshadri, S. and Shrine, N. R. and Cm, van Duijn and Wain, L. and Cooper, J. A. and Humphries, S. E. and Danesh, J. and Bandinelli, S. and Rasheed, A. and Ballantyne, C. M. and Goel, A. and Ballantyne, T. L. and Janipalli, C. S. and Mani, K. R. and Boekholdt, S. Matthijs and Adair, L. S. and Yajnik, C. S. and Mattace-Raso, F. U. and Demirkan, A. and Orru, M. and Lyytikainen, L. P. and Wurz, P. and Dorr, M. and Mi, McCarthy and Kroemer, H. K. and Volker, U. and Galan, P. and Hercberg, S. and Zelenika, D. and Zhai, G. and Meschia, J. F. and Bochud, M. and Sharma, P. and Terzic, J. and Denniff, M. and Wagenknecht, L. E. and Fowkes, F. G. and Arora, P. and Charchar, F. J. and Replication, Diabet Genetics and Rotimi, C. and Bots, M. L. and Brand, E. and Kh, Pietiläinen and Alexander, M. and Talmud, P. J. and Nyberg, F. and Kuh, D. and Laan, M. and Casas, J. P. and Vineis, P. and Marmot, M. G. and Ganesh, S. K. and Cooper, R. S. and Rao, D. C. and Morris, R. W. and Adeyemo, A. and Kivimaki, M. and Miki, T. and Saleheen, D. and Chandak, G. R. and Coresh, J. and Schwarz, P. E. and Navis, G. and Arking, D. E. and Han, B. G. and Meneton, P. and Mj, Sternberg and Rettig, R. and Larson, M. G. and Chakravarti, A. and Newton-Cheh, C. and Levy, D. and Icbp, Int Consortium Blood Pressure and Bouatia-Naji, N. and Rp, Stolk and Rybin, D. and Henneman, P. and Egan, J. M. and Lajunen, T. and Kanoni, S. and Cavalcanti-Proença, C. and Hc, Thomas and Timpson, N. J. and Zabena, C. and Insulin-Related, Meta-Anal Glucose and Artigas,  and Elliott, A. and Roccasecca, R. M. and Pattou, F. and Sethupathy, P. and Bumpstead, S. J. and Bonnefond, A. and Borch-Johnsen, K. and Böttcher, Y. and Brunner, E. and Crisponi, L. and Delplanque, J. and Fedson, A. C. and Fischer-Rosinsky, A. and Frants, R. and Franzosi, M. G. and Goodarzi, M. O. and Graessler, J. and Nj, Wareham and Heath, S. C. and Grundy, S. and Gwilliam, R. and Völzke, H. and Hallmans, G. and Hammond, N. and Han, X. and Hillman, D. R. and Bakker, S. J. and Dm, Waterworth and Hung, J. and Kaakinen, M. and Kesaniemi, Y. A. and Knight, B. and Le Bacquer, O. and Lecoeur, C. and Mahley, R. and Manning, A. K. and Martínez-Larrad, M. T. and McAteer, J. B. and Marmot, M. and Melzer, D. and Meyre, D. and Mukherjee, S. and Jb, Whitfield and Naitza, S. and Neville, M. J. and Orrù, M. and Pakyz, R. and Paolisso, G. and Jc, Witteman and Pearson, D. and Pfeiffer, A. F. and Posthuma, D. and Potter, S. C. and Rolandsson, O. and Sandbaek, A. and Sayer, A. A. and Bh, Wolffenbuttel and Consortium, Genetics Liver Dis Gold and Scheet, P. and Sharp, S. J. and Sigurethsson, G. and Silveira, A. and Simpson, L. and Cs, Fox and Syddall, H. and Syvänen, A. C. and Other, And and An, P. and Varma, D. and Visvikis-Siest, S. and Vogelzangs, N. and Wagner, P. J. and Ariyurek, Y. and Walley, A. and Barter, P. and Ward, K. L. and Ben-Shlomo, Y. and Yarnell, J. W. and Zethelius, B. and Nathan, D. M. and Williams, G. H. and Spranger, J. and Karpe, F. and Cooper, C. and Dedoussis, G. and Serrano-Ríos, M. and Lind, L. and Franks, P. W. and Ebrahim, S. and Buchanan, T. A. and Valle, T. T. and Ee, Schadt and Cao, A. and Mr, Järvelin and Js, Kooner and AlcGen, Alcohol Genome-Wide Assoc and Anthropometric, Genetic Invest and Barroso, },
  doi = {10.1038/ng.970},
  journal = {Nature Genetics},
  month = {oct},
  pages = {1131-1138},
  title = {Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma},
  url = {http://www.nature.com/articles/ng.970.pdf},
  volume = {43},
  year = {2011}
}

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