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American Association for the Advancement of Science, Science, 6225(347), p. 1010-1014, 2015

DOI: 10.1126/science.1259418

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Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

Journal article published in 2015 by Michiel J. L. de Hoon, Louise N. Winteringham, Ernst Wolvetang, Chiyo Yanagi-Mizuochi, Misako Yoneda, Susan Zabierowski, Peter Zhang, Christine Wells, Erik Arner, Carsten O. Daub, Michelle Rönnerblad, A. M. N. Alhendi, Tom C. Freeman, Kristoffer Vitting-Seerup, Ahmad M. N. Alhendi and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Uncaging promoter and enhancer dynamics In order to understand cellular differentiation, it is important to understand the timing of the regulation of gene expression. Arner et al. used cap analysis of gene expression (CAGE) to analyze gene enhancer and promoter activities in a number of human and mouse cell types. The RNA of enhancers was transcribed first, followed by that of transcription factors, and finally by genes that are not transcription factors. Science , this issue p. 1010