Published in
American Association for the Advancement of Science, Science Translational Medicine, 417(9), 2017
DOI: 10.1126/scitranslmed.aag1209
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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance
Journal article published in 2017 by
Yinmeng Yang 
,
M. Eric Kohler ,
Christopher D. Chien ,
Christopher T. Sauter ,
Elad Jacoby ,
Chunhua Yan,
Ying Hu,
Kelsey Wanhainen,
Haiying Qin ,
Terry J. Fry
,
M. Eric Kohler ,
Christopher D. Chien ,
Christopher T. Sauter ,
Elad Jacoby ,
Chunhua Yan,
Ying Hu,
Kelsey Wanhainen,
Haiying Qin ,
Terry J. Fry
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Abstract
TCR engagement induces CD8 CAR T cell exhaustion and poor in vivo functionality in mice.