Links
- ORCID
- Crossref | PDF
- [respiratory-research.com] | PDF
- [repub.eur.nl]
- [www.ncbi.nlm.nih.gov] | PDF
- [www.rug.nl] | PDF
- [pure.rug.nl] | PDF
- [repository.ubn.ru.nl] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
,
Pim A. de Jong,
Bram van Ginneken,
H. M. Boezen (H Marike),
H. Marike Boezen,
H. Marike Boezen,
H. J. M. Groen (Henk),
Harry Jm Groen,
M. Oudkerk (Matthijs),
Mathijs Oudkerk,
Harry J. de Koning,
D. S. Postma (Dirkje)
and other authors.
Abstract
Background: Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical/demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. Methods: 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted >= 5, >= 1-= 5 group was used as reference. Results: Median (Q1-Q3) emphysema severity,5 years' showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p5 years had a yearly decline of 57.5 ml (p Conclusion: Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline.