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American Society of Hematology, Blood, 26(127), p. 3387-3397

DOI: 10.1182/blood-2016-02-699843

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Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

Journal article published in 2016 by Wesley J. Woollard, Venu Pullabhatla, Anna Lorenc, Varsha M. Patel, Rosie M. Butler, Anthony Bayega, Nelema Begum, Farrah Bakr, Kiran Dedhia, Joshua Fisher, Silvia Aguilar-Duran, Charlotte Flanagan, Aria A. Ghasemi, Ricarda M. Hoffmann, Nubia Castillo-Mosquera and other authors.
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Abstract

Key Points Aberrations in genome maintenance and DNA repair genes including POT1 occur at a high frequency in Sézary syndrome. Candidate driver genes and affected pathways in Sézary syndrome show extensive heterogeneity but overlap with other mature T-cell lymphomas.