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Oxford University Press, Nucleic Acids Research, 10(42), p. 6106-6127, 2014

DOI: 10.1093/nar/gku284

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A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

Journal article published in 2014 by Chao Liu, Sriganesh Srihari ORCID, Kim-Anh Lê Cao, Kim-Anh Le Cao, Georgia Chenevix-Trench, Peter T. Simpson, Mark A. Ragan, Kum K. Khanna
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

DNA-damage response machinery is crucial to maintain the genomic integrity of cells, by enabling effective repair of even highly lethal lesions such as DNA double-strand breaks (DSBs). Defects in specific genes acquired through mutations, copy-number alterations or epigenetic changes can alter the balance of these pathways, triggering cancerous potential in cells. Selective killing of cancer cells by sensitizing them to further DNA damage, especially by induction of DSBs, therefore requires careful modulation of DSB-repair pathways.