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MDPI, Sensors, 10(11), p. 9658-9666, 2011

DOI: 10.3390/s111009658

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Numerical Optimization of a Microfluidic Assisted Microarray for the Detection of Biochemical Interactions

Journal article published in 2011 by Emanuele Orabona, Ilaria Rea ORCID, Ivo Rendina, Luca De Stefano ORCID, Luca De Stefano
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Finite element method analysis was applied to the characterization of the biomolecular interactions taking place in a microfluidic assisted microarray. Numerical simulations have been used for the optimization of geometrical and physical parameters of the sensing device. Different configurations have been analyzed and general considerations have been derived. We have shown that a parallel disposition of the sensing area allows the homogeneous formation of the target molecular complex in all the active zones of the microarray. Stationary and time dependent results have also been obtained.