Published in
American Society of Hematology, Blood Advances, 14(1), p. 918-932, 2017
DOI: 10.1182/bloodadvances.2017005173
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In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
Journal article published in 2017 by
Tom N. Durrant 
,
James L. Hutchinson,
Kate J. Heesom,
Karen E. Anderson ,
Len R. Stephens,
Phillip T. Hawkins,
Aaron J. Marshall ,
Samantha F. Moore ,
Ingeborg Hers
,
James L. Hutchinson,
Kate J. Heesom,
Karen E. Anderson ,
Len R. Stephens,
Phillip T. Hawkins,
Aaron J. Marshall ,
Samantha F. Moore ,
Ingeborg Hers
This paper is made freely available by the publisher.
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Abstract
Key PointsWe present the first in-depth analysis of platelet PtdIns(3,4,5)P3-binding proteins, providing a valuable resource for future studies. The PtdIns(3,4,5)P3-binding protein, DAPP1, negatively regulates glycoprotein VI–driven platelet activation and thrombus formation.