Published in
American Society of Hematology, Blood Advances, 19(1), p. 1495-1504, 2017
DOI: 10.1182/bloodadvances.2017007732
Links
Tools
Fibrin and D-dimer bind to monomeric GPVI
Journal article published in 2017 by
Marie-Blanche Onselaer 
,
Alexander T. Hardy ,
Clare Wilson,
Ximena Sanchez,
Amir K. Babar,
Jeanette L. C. Miller,
Callum N. Watson,
Stephanie K. Watson,
Arkadiusz Bonna,
Helen Philippou ,
Andrew B. Herr ,
Diego Mezzano ,
Robert A. S. Ariëns ,
Steve P. Watson
,
Alexander T. Hardy ,
Clare Wilson,
Ximena Sanchez,
Amir K. Babar,
Jeanette L. C. Miller,
Callum N. Watson,
Stephanie K. Watson,
Arkadiusz Bonna,
Helen Philippou ,
Andrew B. Herr ,
Diego Mezzano ,
Robert A. S. Ariëns ,
Steve P. Watson
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Postprint:
archiving forbidden
Data provided by 
Abstract
Key Points GPVI is the major signaling receptor for fibrin in human platelets; the GPVI binding site is located in the fibrin D-dimer region. D-dimer blocks platelet aggregation by fibrin and collagen but not by a collagen-related peptide, suggesting a distinct binding epitope.