Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, Jing; Paz, Katelyn; Flynn, Ryan; Vulic, Ante; Robinson, Tara M.; Lineburg, Katie E.; Alexander, Kylie A.; Meng, Jingjing; Roy, Sabita; Panoskaltsis-Mortari, Angela; Loschi, Michael; Hill, Geoffrey R.; Serody, Jonathan S.; Maillard, Ivan; Miklos, David; Koreth, John; Cutler, Corey S.; Antin, Joseph H.; Ritz, Jerome; MacDonald, Kelli P.; Schacker, Timothy W.; Luznik, Leo; Blazar, Bruce R.

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American Society of Hematology, Blood, 18(129), p. 2570-2580

DOI: 10.1182/blood-2017-01-758854

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Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Journal article published in 2017 by Jing Du, Katelyn Paz, Ryan Flynn, Ante Vulic, Tara M. Robinson, Katie E. Lineburg, Kylie A. Alexander, Jingjing Meng, Sabita Roy, Angela Panoskaltsis-Mortari, Michael Loschi

, Geoffrey R. Hill

, Jonathan S. Serody, Ivan Maillard, David Miklos and other authors.

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Abstract

Key Points Pirfenidone ameliorates cGVHD in murine models with distinct pathophysiology. The efficacy of pirfenidone is associated with inhibition of macrophage infiltration and TGF-β production.

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Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Abstract