Published in
American Society of Hematology, Blood, 16(131), p. 1809-1819
DOI: 10.1182/blood-2017-07-796342
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Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL
Journal article published in 2018 by
Frank Vari,
David Arpon,
Colm Keane 
,
Mark S. Hertzberg,
Dipti Talaulikar,
Sanjiv Jain,
Qingyan Cui,
Erica Han,
Josh Tobin,
Robert Bird,
Donna Cross,
Annette Hernandez,
Clare Gould ,
Simone Birch,
Maher K. Gandhi
,
Mark S. Hertzberg,
Dipti Talaulikar,
Sanjiv Jain,
Qingyan Cui,
Erica Han,
Josh Tobin,
Robert Bird,
Donna Cross,
Annette Hernandez,
Clare Gould ,
Simone Birch,
Maher K. Gandhi
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Abstract
Key Points Expansion of PD-1+ CD3−CD56hiCD16-ve NK cells and PD-L1+ monocytes/macrophages is more prominent in cHL than DLBCL. PD-1 blockade reverses the immune evasion mediated by the interaction of PD-1+ NK cells and PD-L1+ monocytes/macrophages.