Published in
American Society of Hematology, Blood, 14(128), p. 1789-1799
DOI: 10.1182/blood-2016-04-709634
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The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)
Journal article published in 2016 by
Sanjay Khandelwal 
,
Grace M. Lee,
C. Garren Hester,
Mortimer Poncz,
Steven E. McKenzie ,
Bruce S. Sachais,
Lubica Rauova,
Garnett Kelsoe ,
Douglas B. Cines,
Michael Frank,
Gowthami M. Arepally
,
Grace M. Lee,
C. Garren Hester,
Mortimer Poncz,
Steven E. McKenzie ,
Bruce S. Sachais,
Lubica Rauova,
Garnett Kelsoe ,
Douglas B. Cines,
Michael Frank,
Gowthami M. Arepally
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Abstract
Key Points PF4/heparin ultra-large complexes activate complement and bind preferentially to B cells via CR2 (CD21). Complement-fixed PF4/heparin complexes can be detected on circulating B cells in patients receiving heparin therapy.