Published in
American Society of Hematology, Blood, 11(132), p. 1193-1197
DOI: 10.1182/blood-2018-01-829523
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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation
Journal article published in 2018 by
Vincent Muczynski,
Caterina Casari 
,
François Moreau,
Gabriel Aymé,
Charlotte Kawecki ,
Paulette Legendre,
Valerie Proulle,
Olivier D. Christophe ,
Cécile V. Denis ,
Peter J. Lenting
,
François Moreau,
Gabriel Aymé,
Charlotte Kawecki ,
Paulette Legendre,
Valerie Proulle,
Olivier D. Christophe ,
Cécile V. Denis ,
Peter J. Lenting
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Abstract
Key Points The fusion between FVIII and anti-VWF nanobodies increases affinity for VWF 25-fold without compromising FVIII activity. Stabilized VWF binding results in a twofold enhanced circulatory survival of FVIII and reduced anti-FVIII antibody formation.