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American Society of Hematology, Blood, 9(129), p. 1197-1209, 2017

DOI: 10.1182/blood-2016-07-729780

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Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation

Journal article published in 2017 by Meghna U. Naik, Pravin Patel, Randall Derstine, Ramya Turaga, Xi Chen, Kalyan Golla, Keith B. Neeves, Hidenori Ichijo ORCID, Ulhas P. Naik ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Key PointsASK1 regulates TxA2 generation through p38 MAPK-dependent phosphorylation of cPLA2. Because of impaired platelet function, Ask1−/− mice are protected from arterial thrombosis and pulmonary thromboembolism.