Published in
American Society of Hematology, Blood, 9(129), p. 1197-1209, 2017
DOI: 10.1182/blood-2016-07-729780
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Ask1 regulates murine platelet granule secretion, thromboxane A2 generation, and thrombus formation
Journal article published in 2017 by
Meghna U. Naik,
Pravin Patel,
Randall Derstine,
Ramya Turaga,
Xi Chen,
Kalyan Golla,
Keith B. Neeves,
Hidenori Ichijo 
,
Ulhas P. Naik
,
Ulhas P. Naik
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Abstract
Key PointsASK1 regulates TxA2 generation through p38 MAPK-dependent phosphorylation of cPLA2. Because of impaired platelet function, Ask1−/− mice are protected from arterial thrombosis and pulmonary thromboembolism.