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American Society of Hematology, Blood Advances, 27(1), p. 2799-2816, 2017

DOI: 10.1182/bloodadvances.2017004317

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Not just a marker: CD34 on human hematopoietic stem/progenitor cells dominates vascular selectin binding along with CD44

Journal article published in 2017 by Dina B. AbuSamra ORCID, Fajr A. Aleisa ORCID, Asma S. Al-Amoodi ORCID, Heba M. Jalal Ahmed ORCID, Chee Jia Chin, Ayman F. Abuelela ORCID, Ptissam Bergam, Rachid Sougrat ORCID, Jasmeen S. Merzaban ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key PointsHuman HSPCs expressing CD34 exhibit E-selectin binding activity, whereas those lacking CD34 do not. CD34 is a unique E- and P-selectin ligand on human HSPCs that binds with kinetics comparable to other known selectin ligands.