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American Society of Hematology, Blood, 18(129), p. 2547-2556, 2017

DOI: 10.1182/blood-2016-11-753202

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Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Journal article published in 2017 by Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh ORCID, A. Robert MacLeod, Erin H. Norris ORCID, Sidney Strickland
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key PointsThe plasma contact system is activated early in AD mice and temporally correlated with the onset of brain inflammation. Depletion of contact system initiator FXII ameliorates brain pathology and cognitive impairment in AD mice.