Published in
American Society of Hematology, Blood, 18(129), p. 2547-2556, 2017
DOI: 10.1182/blood-2016-11-753202
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Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice
Journal article published in 2017 by
Zu-Lin Chen,
Alexey S. Revenko,
Pradeep Singh 
,
A. Robert MacLeod,
Erin H. Norris ,
Sidney Strickland
,
A. Robert MacLeod,
Erin H. Norris ,
Sidney Strickland
This paper is made freely available by the publisher.
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Abstract
Key PointsThe plasma contact system is activated early in AD mice and temporally correlated with the onset of brain inflammation. Depletion of contact system initiator FXII ameliorates brain pathology and cognitive impairment in AD mice.