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Cell Press, American Journal of Human Genetics, 4(81), p. 829-834, 2007

DOI: 10.1086/521200

Cell Press, American Journal of Human Genetics, 1(82), p. 251, 2008

DOI: 10.1016/j.ajhg.2007.12.008

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Allele-Specific Targeting of microRNAs to HLA-G and Risk of Asthma

Journal article published in 2007 by Zheng Tan, Glenn Randall, Jihua Fan, Blanca Camoretti-Mercado, Rebecca Brockman-Schneider, Lin Pan, Julian Solway, James E. Gern, Robert F. Lemanske, Dan Nicolae, Carole Ober ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child’s HLA-G genotype and the mother’s affection status. Here we report a SNP in the 3′ untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.