National Academy of Sciences, Proceedings of the National Academy of Sciences, 2(115), 2017
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Significance Growing evidence indicates a correlation between colorectal cancer and intestinal dysbiosis or colonization by single bacterial species such as Streptococcus gallolyticus subsp. gallolyticus (SGG), yet a causality link remains to be established. To address this point experimentally, we colonized Apc +/ − Notch-inducible mice with SGG. Apc +/ − is a pioneer somatic mutation driving the occurrence of polyps. We did not observe significant changes in the occurrence or development of polyps in this model. However, we observed a strong SGG colonization in Apc +/ − mice at the expense of resident enterococci. We related this ecological substitution to activation of a SGG-specific bacteriocin whose activity is induced in vivo by the detergent effect of an increased concentration of secondary bile acids in relation to oncogenic situation.