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Wiley, BJOG: An International Journal of Obstetrics and Gynaecology, 11(125), p. 1424-1431

DOI: 10.1111/1471-0528.15216

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Intrauterine adhesions following an induced termination of pregnancy: a nationwide cohort study

Journal article published in 2018 by M. Mentula, J. Männistö, M. Gissler, O. Heikinheimo, M. Niinimäki ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

ObjectiveIntrauterine adhesions (IUAs) are a problematic complication after termination of pregnancy, but their incidence is unknown. Our objective was to assess the incidence of IUAs following induced termination of pregnancy and the risk factors for IUAs.DesignRetrospective cohort study.SettingA nationwide registry study.SampleAll women undergoing induced termination of pregnancy (n = 80 015) in Finland between 2000 and 2008.MethodsThe data were retrieved from the Finnish Abortion Registry and the Hospital Discharge Registry. The diagnosis of IUAs or complications was based on the diagnostic codes (International Statistical Classification of Diseases and Related Health Problems 10th Revision, ICD‐10) and operative codes according to the Nordic Medico‐Statistical Committee (NOMESCO) Classification of Surgical Procedures (NCSP). IUAs were defined as ICD‐10 code N85.6 or operative code LCG02. A subanalysis of IUA cases and five matched controls was performed.Main outcome measuresThe incidence of and risk factors for IUAs.ResultsA total of 12 (1.5 per 10 000) IUA diagnoses were identified from 79 960 eligible induced terminations of pregnancy. The rate of IUAs was 1.5 and 2.0 cases per 10 000 terminations of pregnancy following medically and surgically induced termination of pregnancy, respectively (P = 0.19). In a subgroup analysis of IUA cases and five matched controls, surgical treatment of the remaining products of conception following termination of pregnancy significantly increased the risk of IUAs (odds ratio, OR 5.50; 95% confidence interval, 95% CI 1.46–20.79; P = 0.012).ConclusionIUAs that require further treatment are rare after an induced termination of pregnancy. Surgical evacuation following medical or surgical termination of pregnancy was a risk factor for the diagnosis of IUAs. These results suggest that trauma to a recently pregnant uterus is an important risk factor for IUAs.Tweetable abstractIUA is rare after induced termination of pregnancy (iTOP), but surgical evacuation is a risk factor for IUAs.