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IOP Publishing, Applied Physics Express, 1(10), p. 015501, 2016

DOI: 10.7567/apex.10.015501

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Metastable crystal growth of acetaminophen using solution-mediated phase transformation

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract We report a new method of obtaining the metastable phase form II crystals of acetaminophen. Solution-mediated phase transformation (SMPT) from trihydrate into form II is utilized to obtain form II crystals. SMPT is triggered by seeding form II crystals into a saturated solution including trihydrate crystals, which are less stable than form II crystals. Form II seed crystals gradually grew at the expense of the dissolving trihydrate crystals, and finally, all the trihydrate crystals in solution were transformed into form II crystals in about 4 h. Thus, we conclude that SMPT is effective for the production of form II crystals.