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Frontiers Media, Frontiers in Microbiology, (5), 2014

DOI: 10.3389/fmicb.2014.00126

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New insights into an X-traordinary viral protein

Journal article published in 2014 by Torsten Schaller ORCID, Hélène Bauby, Stéphane Hué, Michael H. Malim, Caroline Goujon
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. Vpx plays a critical role during the early steps of the viral life cycle and has been shown to counteract SAMHD1, a restriction factor in myeloid and resting T cells. However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is likely not its sole role. This review summarizes the current knowledge on this X-traordinary protein.