National Academy of Sciences, Proceedings of the National Academy of Sciences, 37(114), 2017
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Significance Dynamics and interactions of immunocytes infiltrating the pancreas during the natural progression of autoimmune diabetes are largely unknown. The construction of diabetes-prone nonobese diabetic mice with a panel of fluorescent reporters that illume infiltrating cells of the innate and adaptive immune systems, combined with intravital imaging of the pancreas, provide novel perspectives on the autoimmune process and on the ballet between aggressive and regulatory cells.