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PAGEpress, Mediterranean Journal of Hematology and Infectious Diseases, 1(5), p. e2013008, 2013

DOI: 10.4084/mjhid.2013.008

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An Urologic Face of Chronic Lymphocytic Leukemia: Sequential Prostatic and Penis Localization

Journal article published in 2013 by Giovanni D’Arena, Roberto Guariglia, Oreste Villani, Maria Carmen Martorelli, Giuseppe Pietrantuono, Giovanna Mansueto, Giuseppe Patitucci, Emilio Imbriani, Tommaso Masciandaro, Ludovica Borgia, Giulia Vita, Fiorella D’Auria ORCID, Teodora Statuto, Pellegrino Musto
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We report a patient with chronic lymphocytic leukemia (CLL) in whom a leukemic involvement of prostate and penis occurred in the advanced phase of his disease. Obstructive urinary symptoms were indicative of prostatic CLL infiltration, followed by the occurrence of an ulcerative lesion on the glans. Histologic examination confirmed the neoplastic B-cell infiltration. Both localizations responded to conventional treatments. A review of the literature confirms that leukemic involvement of the genito-urinary system is uncommon in CLL patients. However, such an involvement should be considered in CLL patients with urologic symptoms and a long history of the disease.