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Cold Spring Harbor Perspectives in Medicine, 2(3), p. a013573-a013573

DOI: 10.1101/cshperspect.a013573

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General Aspects and Recent Advances on Bacterial Protein Toxins

Journal article published in 2013 by Emmanuel Lemichez ORCID, Joseph T. Barbieri
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Bacterial pathogens produce protein toxins to influence host-pathogen interactions and tip the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify host-specific targets through posttranslational modifications (PTMs) or noncovalent interactions that may inhibit or activate host cell physiology to benefit the pathogen. Recent advances have identified new PTMs and host targets for toxin action. Understanding the mechanisms of toxin action provides a basis to develop vaccines and therapies to combat bacterial pathogens and to develop new strategies to use toxin derivatives for the treatment of human disease.