Dissemin is shutting down on January 1st, 2025

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Elsevier, Bioorganic and Medicinal Chemistry Letters, 11(5), p. 1125-1130, 1995

DOI: 10.1016/0960-894x(95)00178-v

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Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme. © 1995.