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Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort.

Journal article published in 2014 by J. Ose, H. Schock, Ph H. Peeters, Nc C. Onland-Moret, E. Weiderpass, K. Overvad, A. Tjonneland, A. Trichopoulou, D. Trichopoulos, R. Tumino, M. Popovic, M. Obón-Santacana, Mj-J. Sánchez, Rc C. Travis, S. Rinaldi and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

BACKGROUND: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. RESULTS: We observed no association between IGF-I and EOC overall or by tumour characteristics. CONCLUSIONS: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.