Published in
American Society for Microbiology, Infection and Immunity, 9(86), 2018
DOI: 10.1128/iai.00114-18
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Tailoring a Plasmodium vivax Vaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors
Journal article published in 2018 by
Erwan Atcheson,
Karolis Bauza,
Ahmed M. Salman 
,
Eduardo Alves,
Joshua Blight,
Martha Eva Viveros-Sandoval,
Chris J. Janse,
Shahid M. Khan,
Adrian V. S. Hill,
Arturo Reyes-Sandoval
,
Eduardo Alves,
Joshua Blight,
Martha Eva Viveros-Sandoval,
Chris J. Janse,
Shahid M. Khan,
Adrian V. S. Hill,
Arturo Reyes-Sandoval
This paper is made freely available by the publisher.
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Abstract
Vivax malaria remains one of the most serious and neglected tropical diseases, with 132 to 391 million clinical cases per year and 2.5 billion people at risk of infection. A vaccine against Plasmodium vivax could have more impact than any other intervention, and the use of a vaccine targeting multiple antigens may result in higher efficacy against sporozoite infection than targeting a single antigen.