Published in
American Society of Hematology, Blood, 16(128), p. 2022-2032
DOI: 10.1182/blood-2016-02-699959
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Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation
Journal article published in 2016 by
Alicia Aguilar,
Fabien Pertuy,
Anita Eckly,
Catherine Strassel 
,
Dominique Collin,
Christian Gachet,
François Lanza,
Catherine Leon
,
Dominique Collin,
Christian Gachet,
François Lanza,
Catherine Leon
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Abstract
Key Points Mimicking 3D BM stiffness improves MK maturation with in situ–like morphology and higher ploidy and proplatelet formation. The myosin IIA and MKL1 pathways contribute to 3D hydrogel medium-mediated increased proplatelet formation.