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Oxford University Press (OUP), Bioinformatics, 11(26), p. 1468-1469

DOI: 10.1093/bioinformatics/btq147

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FastEpistasis: a high performance computing solution for quantitative trait epistasis

Journal article published in 2010 by Thierry Schüpbach, Ioannis Xenarios ORCID, Sven Bergmann, Karen Kapur
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Genome-wide association studies have become widely used tools to study effects of genetic variants on complex diseases. While it is of great interest to extend existing analysis methods by considering interaction effects between pairs of loci, the large number of possible tests presents a significant computational challenge. The number of computations is further multiplied in the study of gene expression quantitative trait mapping, in which tests are performed for thousands of gene phenotypes simultaneously.