Springer Verlag, Journal of Nanoparticle Research, 8(15)
DOI: 10.1007/s11051-013-1818-8
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In the quest for biocompatible nanocarriers for biomedical applications a great deal of effort is put on engineering the nanocomposites surface in order to render them specific to the particular purpose. We developed biocompatible PLGA-b-PEG-based nanoparticles carrying a double functionality (i.e. carboxylic and acetylenic) able to serve as flexible highly selective grafting centers for cancer diagnosis and treatment. As a proof of concept the nanocarrier was successfully functionalized with a tailored fluorescent molecule by means of click chemistry and with a targeting agent specific for Glioblastoma Multiforme via amidic bond formation. ; JRC.I.4-Nanobiosciences