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De Gruyter, Zeitschrift für Naturforschung C, 11-12(73), p. 449-455, 2018

DOI: 10.1515/znc-2017-0162

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Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.

Journal article published in 2018 by D. M. De Oliveira ORCID, Djalma M. de Oliveira, Cristiane B. Pereira, Graziele Mendes, Jochen Junker, Markus Kolloff, Luiz H. Rosa, Carlos A. Rosa, Tânia M. A. Alves, Carlos L. Zani, Susana Johann ORCID, Betania B. Cota ORCID
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Abstract

Abstract The endophytic fungus Mycosphaerella sp. (UFMGCB2032) was isolated from the healthy leaves of Eugenia bimarginata, a plant from the Brazilian savanna. Two novel usnic acid derivatives, mycousfuranine (1) and mycousnicdiol (2), were isolated from the ethyl acetate extract, and their structure was elucidated by NMR and MS analyses. Compounds 1 and 2 exhibited moderate antifungal activities against Cryptococcus neoformans and Cryptococcus gattii, each with minimum inhibitory concentration values of 50.0 μg/mL and 250.0 μg/mL, respectively.