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Wiley, British Journal of Clinical Pharmacology, 6(75), p. 1506-1515, 2013

DOI: 10.1111/bcp.12052

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The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery

Journal article published in 2013 by Sabine Jgm G. M. Ahlers, Laure L. Elens ORCID, Laura van Gulik, Ron H. van Schaik, Eric Pa A. van Dongen, Peter Bruins, Dick Tibboel, Catherijne Aj J. Knibbe
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated patients undergoing an unavoidable painful routine procedure after cardiac surgery.