Dissemin is shutting down on January 1st, 2025

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EMBO Press, The EMBO Journal, 6(31), p. 1331-1333, 2012

DOI: 10.1038/emboj.2012.34

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Ready, STAT, go: transcription factors on the move

Journal article published in 2012 by Valentina Di Liberto ORCID, Valeria Cavalli
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this issue of The EMBO Journal, Ben-Yaakov et al (2012) explore the contribution of transcription factors (TFs) in directly communicating information about injury between the axon and the nucleus. They show that multiple TFs bind the retrograde molecular motor dynein in injured axons. Focusing on one TF family, the authors reveal that STAT3 is locally translated and activated in injured axons, and then transported retrogradely to the nucleus to promote survival of peripheral sensory neurons.