Published in
American Society of Hematology, Blood, 6(131), p. 621-635
DOI: 10.1182/blood-2017-01-762393
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Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice
Journal article published in 2018 by
Ayana Kon 
,
Satoshi Yamazaki,
Yasuhito Nannya,
Keisuke Kataoka ,
Yasunori Ota,
Masahiro Marshall Nakagawa ,
Kenichi Yoshida ,
Yusuke Shiozawa,
Maiko Morita,
Tetsuichi Yoshizato ,
Masashi Sanada ,
Manabu Nakayama,
Haruhiko Koseki ,
Hiromitsu Nakauchi ,
Seishi Ogawa
,
Satoshi Yamazaki,
Yasuhito Nannya,
Keisuke Kataoka ,
Yasunori Ota,
Masahiro Marshall Nakagawa ,
Kenichi Yoshida ,
Yusuke Shiozawa,
Maiko Morita,
Tetsuichi Yoshizato ,
Masashi Sanada ,
Manabu Nakayama,
Haruhiko Koseki ,
Hiromitsu Nakauchi ,
Seishi Ogawa
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Abstract
Key Points Blood-specific expression of the Srsf2 P95H mutant results in decreased stem/progenitor cell numbers and a reduced repopulation capacity. Srsf2 P95H mutation by itself is not sufficient to develop MDS but contributes to the MDS phenotype in transplantation settings.