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Wiley Open Access, Influenza and Other Respiratory Viruses, 5(8), p. 580-584, 2014

DOI: 10.1111/irv.12269

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Use of fractional factorial design to study the compatibility of viral ribonucleoprotein gene segments of human H7N9 virus and circulating human influenza subtypes

Journal article published in 2014 by Alex W. H. Chin, Chris K. P. Mok, Huachen Zhu, Yi Guan, Joseph S. M. Peiris, Leo L. M. Poon ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Avian H7N9 influenza viruses may pose a further threat to humans by reassortment with human viruses, which could lead to generation of novel reassortants with enhanced polymerase activity. We previously established a novel statistical approach to study the polymerase activity of reassorted vRNPs (Influenza Other Respir Viruses. 2013;7:969-78). Here, we report the use of this method to study recombinant vRNPs with subunits derived from human H1N1, H3N2, and H7N9 viruses. Our results demonstrate that some reassortant vRNPs with subunits derived from the H7N9 and other human viruses can have much higher polymerase activities than the wild-type levels.