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MDPI, International Journal of Molecular Sciences, 10(14), p. 20793-20808, 2013

DOI: 10.3390/ijms141020793

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Lipid Transport and Metabolism in Healthy and Osteoarthritic Cartilage

Journal article published in 2013 by Amanda Villalvilla ORCID, Rodolfo Gómez, Raquel Largo ORCID, Gabriel Herrero-Beaumont ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.