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Bohn Stafleu van Loghum, Critical Care, 4(17), p. 162

DOI: 10.1186/cc12778

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Early alterations of B cells in patients with septic shock: another piece in the complex puzzle of the immune response in sepsis

Journal article published in 2013 by Massimo Girardis ORCID, Andrea Cossarizza
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Impairment of the inflammatory-immune response is currently accepted as a hallmark of severe sepsis even in the early stages of the disease. In this context, the alterations of the circulating B-lymphocytes have never been described in detail. The study by Monserrat and colleagues in the previous issue of Critical Care indicated that, in patients with septic shock, the B-cell compartment is early and deeply altered with different patterns in subset distribution and activation between survivors and non-survivors.