Published in
Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 6(109), p. 814-819, 2014
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- Instituto Oswaldo Cruz, Ministério da Saúde
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- [www.ncbi.nlm.nih.gov] | PDF
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- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
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Tools
Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current enotyping procedures: a population-based study in northeast Mexico
,
Molina-Salinas,Gloria María,
Silva-Ramírez,Beatriz,
Gerardo Raymundo Padilla-Rivas,
Padilla-Rivas,Gerardo Raymundo,
Vera-Cabrera,Lucio,
Víctor Manuel Torres-De-La-Cruz,
Martínez-Martínez,Yazmin Berenice
and other authors.
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Abstract
The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman’s rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p