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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(61), 2017

DOI: 10.1128/aac.01757-17

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New Variant of mcr-3 in an Extensively Drug-Resistant Escherichia coli Clinical Isolate Carrying mcr-1 and bla NDM-5

Journal article published in 2017 by Lu Liu, Yu Feng, Xiaoxia Zhang, Alan McNally, Zhiyong Zong ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

ABSTRACT A colistin- and carbapenem-resistant Escherichia coli clinical isolate was found to carry two plasmid-borne colistin-resistant genes, mcr-1 and the newly identified mcr-3 , and a carbapenemase gene, bla NDM-5 . mcr-3 is a new variant ( mcr-3.5 ) in the isolate and encodes three amino acid substitutions compared with the original MCR-3. mcr-3 was carried by a Tn As3 -like transposon on a self-transmissible IncP plasmid in the isolate, highlighting that mcr-3 may have widely spread.