Published in
American Society of Hematology, Blood, 23(128), p. 2642-2654, 2016
DOI: 10.1182/blood-2016-03-703454
Links
Tools
Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors
Journal article published in 2016 by
Antonis Dagklis,
Sofie Demeyer,
Jolien De Bie,
Enrico Radaelli,
Daphnie Pauwels,
Sandrine Degryse,
Olga Gielen,
Carmen Vicente 
,
Roel Vandepoel,
Ellen Geerdens,
Anne Uyttebroeck,
Nancy Boeckx,
Charles E. de Bock ,
Jan Cools
,
Roel Vandepoel,
Ellen Geerdens,
Anne Uyttebroeck,
Nancy Boeckx,
Charles E. de Bock ,
Jan Cools
This paper is made freely available by the publisher.
Full text: Download
Preprint: archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
Key Points A subset of T-ALL cases show high expression of hedgehog pathway genes including the SHH ligand and the GLI1 transcription factor. T-ALL samples with high GLI1 expression levels respond to hedgehog inhibitor treatment in vitro and in vivo.