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American Society for Microbiology, Journal of Virology, 16(83), p. 8270-8275, 2009

DOI: 10.1128/jvi.00670-09

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Truncation of TRIM5 in the Feliformia Explains the Absence of Retroviral Restriction in Cells of the Domestic Cat

Journal article published in 2009 by William A. McEwan ORCID, Torsten Schaller ORCID, Laura M. Ylinen, Margaret J. Hosie, Greg J. Towers ORCID, Brian J. Willett
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT TRIM5α mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved across the Feliformia . Cat TRIM5 displayed no restriction activity, but ectopic expression conferred a dominant negative effect against human TRIM5α. Our findings explain the absence of retroviral restriction in cat cells and suggest that disruption of the TRIM5 locus has arisen independently at least twice in the Carnivora , with implications concerning the evolution of the host and pathogen in this taxon.