Dissemin is shutting down on January 1st, 2025

Published in

Cambridge University Press, European Psychiatry, S1(41), p. S226-S226, 2017

DOI: 10.1016/j.eurpsy.2017.01.2225

Links

Tools

Export citation

Search in Google Scholar

Clinical high risk symptoms and criteria in the community: Prevalence, clinical significance and risk factors for their occurrence

Journal article published in 2017 by F. Schultze-Lutter, C. Michel, B. G. Schimmelmann, S. Ruhrmann ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Green circle
Published version: archiving allowed
Data provided by SHERPA/RoMEO

Abstract

IntroductionIn clinical samples, symptomatic ultra-high risk (UHR) criteria and the basic symptom criterion “cognitive disturbances” perform well in predicting psychosis, and best when both approaches are combined.ObjectiveHowever, little-to-nothing is known about clinical high risk (CHR) and their constituent symptoms in the community.AimsWe studied the prevalence, clinical relevance, and moderators of CHR criteria and symptoms in the community.MethodRegression analyses involved 2683 community participants (age 16–40 years; response rate: 63.4%). Semi-structured telephone interviews were performed by well-trained psychologists.ResultsLifetime and current CHR symptoms were reported by 21.1% and 13.8% of interviewees. Frequency of symptoms was mostly low, only 2.4% met any CHR criterion. A stepwise relationship underlay the association of the two types of CHR symptoms and criteria with the presence of mental disorders and functional deficits, with odds ratios being highest (7.4–31.8) when UHR and basic symptoms occurred together. Report of a family history of mental disorder generally increased risk for CHR symptoms. While younger age increased risk for basic symptoms, lifetime substance misuse and trauma increased risk for UHR symptoms.ConclusionsPrevalence of CHR criteria was within the to-be-expected range from prevalence rates of psychoses. Clinical relevance of both CHR symptoms and criteria increased in a stepwise manner from basic symptoms via UHR symptoms to their combined presence, reinforcing the clinical utility of their combined use. The risk factors selectively associated with basic and UHR symptoms support developmental models relating basic symptoms to neurobiological and UHR symptoms to psychological factors.Disclosure of interestThe authors have not supplied their declaration of competing interest.