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American Society of Hematology, Blood, 5(128), p. 638-649, 2016

DOI: 10.1182/blood-2016-01-694810

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Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

Journal article published in 2016 by Shuhei Koide, Motohiko Oshima, Keiyo Takubo, Satoshi Yamazaki, Eriko Nitta, Atsunori Saraya, Kazumasa Aoyama, Yuko Kato, Satoru Miyagi, Yaeko Nakajima-Takagi, Tetsuhiro Chiba, Hirotaka Matsui, Fumio Arai, Yutaka Suzuki, Hiroshi Kimura and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points Setdb1, an H3K9 histone methyltransferase, is essential for the maintenance of HSPCs. Setdb1 restricts the activation of nonhematopoietic genes, such as gluconeogenic pathway genes, to maintain HSPCs.