Published in
Wiley, British Journal of Clinical Pharmacology, 6(82), p. 1477-1485, 2016
DOI: 10.1111/bcp.13068
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Oral supplementation with L-homoarginine in young volunteers
Journal article published in 2016 by
Dorothee Atzler,
Mirjam Schönhoff,
Kathrin Cordts,
Imke Ortland,
Julia Hoppe,
Friedhelm C. Hummel,
Christian Gerloff 
,
Ulrich Jaehde,
Annika Jagodzinski,
Rainer H. Böger,
Chi-Un Choe,
Edzard Schwedhelm
,
Ulrich Jaehde,
Annika Jagodzinski,
Rainer H. Böger,
Chi-Un Choe,
Edzard Schwedhelm
This paper is made freely available by the publisher.
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Abstract
Low blood concentrations of the naturally occurring amino acid L-homoarginine (L-hArg) are related to impaired cardiovascular outcome and mortality in humans and animals. L-hArg is a weak substrate of nitric oxide synthase and an inhibitor of arginases in vitro. The aim of our study was to obtain kinetic and dynamic data after oral L-hArg supplementation.