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Future Medicine, Future Virology, 9(13), p. 637-645, 2018

DOI: 10.2217/fvl-2018-0055

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microRNAs 29, 150, 155, 223 level and their relation to viral and immunological markers in HIV-1 infected naive patients

Journal article published in 2018 by Mohsen Moghoofei, Farah Bokharaei-Salim, Maryam Esghaei, Hossein Keyvani, Maryam Honardoost ORCID, Shayan Mostafaei, Amir Ghasemi, Ahmad Tavakoli, Davod Javanmard, Farhad Babaei, Saba Garshasbi, Seyed Hamidreza Monavari
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Aim: The aim of this study was to assess the relationship between microRNAs and viral and immunological markers in HIV-1 infection. Materials & methods: The expression level of miRNAs was evaluated in 60 HIV-1 patients and 20 healthy controls using real-time PCR assays. Results: The results showed that among all miRNAs, miR-29 and miR-150 were significantly downregulated in HIV-1 patients compared with healthy controls, while miR-155 and miR-223 were significantly upregulated compared with healthy controls (p < 0.001 for all comparisons). Conclusion: The mentioned miRNAs seem to influence the clinical progression of HIV-1 infection in naive patients. Moreover, determining the profiles of miRNAs involved in the pathogenesis of HIV infection and manipulating these miRNAs could lead to opening a new gate to HIV-1 infection control.