Published in
American Society for Microbiology, Infection and Immunity, 9(86), 2018
DOI: 10.1128/iai.00394-18
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Delineating the Physiological Roles of the PE and Catalytic Domains of LipY in Lipid Consumption in Mycobacterium-Infected Foamy Macrophages
Journal article published in 2018 by
Pierre Santucci,
Sadia Diomandé,
Isabelle Poncin,
Laetitia Alibaud,
Albertus Viljoen,
Laurent Kremer 
,
Chantal de Chastellier,
Stéphane Canaan
,
Chantal de Chastellier,
Stéphane Canaan
This paper is made freely available by the publisher.
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Abstract
Within tuberculous granulomas, a subpopulation of Mycobacterium tuberculosis resides inside foamy macrophages (FM) that contain abundant cytoplasmic lipid bodies (LB) filled with triacylglycerol (TAG). Upon fusion of LB with M. tuberculosis -containing phagosomes, TAG is hydrolyzed and reprocessed by the bacteria into their own lipids, which accumulate as intracytosolic lipid inclusions (ILI).