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American Society of Hematology, Blood, p. blood-2018-01-825240

DOI: 10.1182/blood-2018-01-825240

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Myeloma-escape after stem cell transplantation is a consequence of T cell exhaustion and is prevented by TIGIT blockade

Journal article published in 2018 by Simone A. Minnie ORCID, Rachel D. Kuns, Kate H. Gartlan, Ping Zhang, Andrew N. Wilkinson, Luke Samson, Camille Guillerey, Christian Engwerda, Kelli P. A. MacDonald, Mark J. Smyth, Kate A. Markey, Slavica Vuckovic ORCID, Geoffrey R. Hill ORCID
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Abstract

Key Points Myeloma promotes CD8+ T-cell exhaustion and IL-10 secretion from dendritic cells. PD-1 and TIGIT-targeted checkpoint inhibition is effective after SCT.